Download 10 Questions on Advanced Clinical Immunohematology - Exam | CLS 3311 and more Exams Chemistry in PDF only on Docsity! 1 CLS 3311 Advanced Immunohematology Transfusion Reaction Lecture Objectives The student will be given the opportunity to: 1. Define the term transfusion reaction. 2. Compare & contrast intravascular hemolysis with extra-vascular hemolysis in terms of site of destruction and mechanism of destruction. 3. Compare & contrast the symptoms and expected test results which may be observed in the following types of transfusion reactions: a. febrile b. allergic c. anaphylactic d. non-cardiogenic pulmonary e. cardiovascular overload f. acute hemolytic g. delayed hemolytic h. bacterial contamination i. non-immunologic hemolysis 4. Define the most common causes of each of the transfusion reactions listed in #3, a through i. 5. Compare the management techniques for patients with a history of the following reactions including appropriate blood component for future transfusions: a. febrile b. allergic c. anaphylactic d. cardiovascular overload e. hemolytic reactions f. bacterial contamination. 6. Define graft vs. host disease and describe the method for preventing graft versus host reactions. 7. Explain how to handle the transfusion reaction patient in the future, i.e., what modifications of the blood component are necessary and/or what special testing must be performed to insure a safe and effective transfusion in the future. 8. Correlate preliminary checks and tests with clinical evidence to determine the cause of transfusion reaction for: Febrile nonhemolytic transfusion reactions, circulatory overload, allergic reactions, hemolytic reaction due to unexpected alloantibody, and reaction due to bacterial contamination. 9. Describe follow up reports of infectious disease transmission associated with transfusion including review of test results on donor blood and patient blood sample, and performance of “look back” procedure. 10. Explain the technique used to separate transfused red blood cells from autologous red blood cells by capillary centrifugation and perform appropriate testing on separated cells.
