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Biliary Passage
* Gall Bladder *
Ligamentum teres
-_ Fundus
Gall Zs
Bladder [— Body Ze
\4 } , Hepatic artery
—— Neck
Cystic duct
Porta hepatis
Right hepatic duct and artery Left hepatic duct and
Artery
Cystic a. -
Accessory cystic arteries Common hepatic duct
Inferior surface of liver Hepatic A.
Common bile duct
Gall Bladder
Hartmann's
pouch Cystic duct
ILV.C.
Opening to lesser
sac
1° part of duodenum
Gastro-duodenal a-
2™ part of duodenum
Head of pancreas
Common bile duct
Empyema
of gall bladder
c. Gangrenous inflammation:(rare ). Persistence of obstruction
— high pressure inside gall bladder — obstruction of blood
supply in the wall or thrombosis of blood vessels — gangrene
and perforation of the wall.
Gangrenous cholecystitis
d. Emphysematous cholecystitis. Rare, in diabetics due to
infection with anerobic gas forming organism e.g colistridia.
Emphysematous cholecystitis
2. Acute non-calcular cholecystitis :(Rare , 2%)
e It is more dangerous than calcular cholecystitis .
e This occur in ICU patient suffering from major
burn, major trauma , sever shock or infection
(eg. typhoid).
¢ Changes in the composition of bile or ischaemia
of G.B , may be the cause.
« The condition is very serious because it is
unsuspected and diagnosis is delayed .
e Ultrasound is diagnostic & treatment is urgent
cholecystectomy.
Gallstone blocking
cystic duct
Gallstones
formin
in gallbladder
Stomach
* Consequences and Complications:
1, With treatment , reso/ution in most cases , the stone
dislodges and the obstruction is relieved with drainage of bile
and gradual resolution of inflammation .
2. Chronicity is the commonest complications , with more stones
formation and recurrent acute exacerbations.
3. Local spread of infection \eading to ascending cholangitis ,
cholangiohepatitis and descending pancreatitis.
4.Gangrene & Perforation :(rare )
+ This usually leads to \ocalized peritonitis ( as a defensive
mechanism the greater omentum , duodenum and colon adhere
to the gall bladder ) or rarely ( 1 % ) generalized peritonitis .
¢The fundus is th most liable because it is the least vascular part
of the G.B.
«Less commonly perforation may occur at the neck due to pressure
necrosis by an impacted stone.
¢ Gangrene of gall bladder is rare because it has numerous
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b-Local:
1. Tenderness, rebound tenderness and rigidity in the right
hypochondrium maximum at the tip of right 9". costal cartilage
leading to difficult to palpte GB distention .
2.Limitation of abdominal mobility with respiration in the right
hypochondrium.
3. A mass may be felt below the right costal margin in empyema or
mucocele of G.B. (mention the characters of G.B. mass). It is
difficult to palpate due to tenderness and rigidity .
4. Murphy's sign : A gentle pressure is applied just below the right
costal margin then ask the pt, to take a deep breath ~ the pt. will
catch her breath. Sonographic Murphy's sign is more accurate
in the diagnosis .
Wiemmicarenerlite
Of eliciting Murphy’
eee saa
5 . Boas’ sign : An area of hyperaeshtesia between 9-11 ribs posterior
on the right side ( below right scapula ).
Boas sign
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* Investigations:
1. Blood picture: Shows leucocytosis.
2. Liver function tests are usually normal or rarely serum billirubin
may be raised.
3. Ultrasonography: (Most important & first investigation)
* It Shows distended G.B., thick wall, micro abscesses & serosal
oedema.
* It shows 98 % of GB stones and 1/3 of bile duct stones .
* Dilatation of CBD and intrahepatic biliary passage indicates
stones in the CBD .
e It is non-invasive, easy & inexpensive.
4. Plain x-ray : ( replaced by U/S & rarely done nowadays )
e It shows radio-opaque stones (10-20 %) .
e Presence of air in the GB in emphysematous cholecystitis .
5. CT scan may be needed in doubtful cases .
6. HIDA scan : °°"Tc is given IV to be excreted rapidly by the liver
to visualize the biliary passage . Non-visualization of GB
IHBD
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indicate obstruction of cystic duct and confirm the diagnosis of
acute cholecystitis .
* D.D : of pain in the right hypochondrium
1- Hepatobiliary diseases :
Cholangitis
Biliary colic Acute cholecystitis
Pain pain in right hypochondriu
Duration
of pain
usually less than 6 usually more than 6 hours Few days
hours
Fever
no fever
low grade fever
high fever & rigor
leucocytosis
no leucocytosis
Mild leucocytosis
Severe leucocytosis
jaundice
no jaundice
e Chronic cholecystitis
usually no jaundice
e Hepatitis and amoebic liver abscess
2- Acute pancreatitis
Jaundice (
Charcot’s triade )
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, size of the mass , early manifestations of complications and
ultrasound .
eResult of conservative treatment:
1. In 90% of cases the acute attack subside — delayed or
interval cholecystectomy after 6 weeks .
2. Rarely failure of conservative treatment or development of
complications :
a) In fit patient : urgent cholecystectomy . or
b) In unfit patient : cholecystostomy ( the fundus of gall
bladder is opened , remove of stones and drainage of gall
bladder by a tube for one week ) followed after 6 weeks by
elective cholecystectomy .
Urgent cholecystectomy : After rapid pre-operative preparation ( within
few hours ) , cholecystectomy should be done as emergency in the
following patients :
1- Elderly diabetic ( high mortality & morbidity with time)
2- Pain and tenderness spread across the abdomen(Suggest perforation)
3- Deterioration of the general condition of the patient under
conservative treatment .
4- Development of complications .
5- Acute non-calcular cholecystitis .
6- Doubtful diagnosis with deterioration of the general condition of the
patient .
* There is conservative treatment in acute cholecystitis while in
acute appendicitis there is no conservative treatment due to the
followings
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Acute cholecystitis
Acute appendicitis
1-GB receive arterial supply
from cystic artery and many
blood vessels from the
undersurface of the liver .
1- Appendix receive only single
arterial supply only from
appendicular artery and its tip
receive an end branch from
this artery .
2-Less virulent organism
2-Highly virulent organism
3-GB has thin wall dispensable
with mild increase in its intra-
luminal pressure .
2-Appendix has thick rigid wall
indispensable with marked increase in
its intra- luminal pressure .
4- Rare late perforation
4- Early common perforation
Anatomy of the Gallbladder
Cystic duct
Enlargement of gall blade, tle
‘ducts and arteries
bile duct
Ascending branch
of ileocolic artery
leocolic artery
Anterior and posterior cecal
‘branches of ileocolic artery
Ileal branch of
ileocolic artery
Mesoappendix
Appendicular
artery
Appendix