AD genetic vaccine AD genetic vaccine, Study Guides, Projects, Research of Health sciences

Download AD genetic vaccine AD genetic vaccine and more Study Guides, Projects, Research Health sciences in PDF only on Docsity! Vaccine The development of Alzheimer’s vaccine primarily aims at two targets, amyloid beta (Aβ) and tau ) and tau protein. Their accumulation during Alzheimer’s disease (AD) progression can cause neuronal damage. Therefore, researchers hope that the immune system is able to recognize the antigenic characteristics of the two proteins and produce antibodies against them. However, current research indicates that almost all attempts to develop vaccines using Aβ) and tau end in disappointment, probably because the vaccine has the wrong immunogen, the B-cell epitope of Aβ) and tau , which stimulates an antibody response that releases the neurotoxic soluble Aβ) and tau oligomers trapped in plaque, and the use of proinflammatory adjuvants that induce a destructive inflammatory autoimmune response. Thus, the development of a safe and effective Alzheimer’s vaccine that induces protective antibody production requires new strategies, and lessons learned from past vaccine failures should be considered.