Amino Acid Derivatives - Biochemistry - Lecture Slides, Slides of Biochemistry

Download Amino Acid Derivatives - Biochemistry - Lecture Slides and more Slides Biochemistry in PDF only on Docsity! BIOSYNTHESIS OF AMINO ACIDS Alanine Pyruvate a-Ketoglutarate OAA Aspartate Asparagine Glutamate Glutamine Krebs cycle Lysine Threonine Isoleucine Urea Homoserine Methionine Nucleotides Histidine Tryptophan Ornithine Nucleotides Amino sugars Arginine Urea Creatine phosphate Proline Docsity.com COO- CH2 CHO- CH2 H3N-C-H H2C CH2 C N CH COO- H COO- CH2 COO- CH2 H3N-C-H NADPH Glu H2C CH2 C N CH COO- H2 H L-Proline 1-Pyrroline carboxylic acid NADPH PROLINE BIOSYNTHESIS Glutamate semialdehyde Docsity.com COO- CH2 COO- H3N-C-H + COO- CH2 CHO H3N-C-H + COO- CH2 C~OPO3 = H3N-C-H + O ATP NADPH NADPH COO- CH2 CH2OH H3N-C-H + Homoserine COO- H-C-OH CH3 H3N-C-H + Threonine COO- CH2 CH2 H3N-C-H + SH L-Methionine Methyl-THF B12 Homocysteine L-Aspartate Aspartyl--PO4 p646 OAA/Aspartate -Aspartyl- semialdehyde Docsity.com Serine Homocysteine L-Cysteine a-ketobutyrate S CH2 CH2 H3N-CH COO- CH2 CH COO- NH3 + CH2-SH CH COO- NH3 + CH3 CH2 C=O COO- Cystathione -lyase Cystathionine Docsity.com Neurotransmitters • Norepinephrine Phenylalanine • Dopamine Phenylalanine • Serotonin Tryptophan • GABA Glutamate Docsity.com Famous Decarboxylations N N H CH2-C-COO - NH3 + H H + N N H CH2-CH2-NH3 + H + N CH2-C-COO - H NH3 + N CH2-CH2-NH3 + HO Histamine (A-CHOO!) L-Histidine L-Tryptophan Serotonin 5-hydroxytryptamine CO2 CO2 O2 Docsity.com COO- CH2 COO- CH2 H3N-C-H CH2 COO- CH2 H3N-C-H H -Aminobutyric Acid (GABA) L-Glutamate CO2 Docsity.com CH2-C-COO - NH3 + H CH2-C-COO - NH3 + H HO CH2-C-COO - NH3 + H HO HO Phenylalanine Tyrosine L-DOPA Catechol CH2-C-H NH3 + H HO HO Dopamine CO2 Catecholamine Docsity.com CH2-C-H NH3 + H HO HO C-CH2-NH3 + H HO HO OH Dopamine Norepinephrine O2 C-CH2-N-CH3 H HO HO OH H Epinephrine SAM (Adrenaline) Docsity.com COO H3N-C-H CH2 CH2 COO – – COO H3N-C-H CH2 CH2 COO – – COO H3N-C-H CH2 CH2 COO – – H2C CH2 C N C COO H H H2C CH2 C N C COO H H2 H Docsity.com