Chemistry Graduate Programs, Study notes of Organic Chemistry

Download Chemistry Graduate Programs and more Study notes Organic Chemistry in PDF only on Docsity! 2022-2023 Academic Catalog 1 Table of Contents Chemistry...............................................................................................................1 Chemistry Programs leading to the Doctor of Philosophy and Master of Science degrees may be undertaken in the general areas of analytical, biochemistry, inorganic, materials, organic, and physical chemistry. The doctoral degree in chemistry is a research degree. To be awarded this degree, the student must demonstrate, to the satisfaction of the graduate committee, the ability to conduct original and independent research within some area of chemistry and must make an original contribution to the science. The M.S. in Chemistry degree also requires a research project, but with less emphasis on originality and independence. Master of Science (M.S.) in Chemistry Doctorate of Philosophy (Ph.D.) in Chemistry Admission Each student must have a baccalaureate degree in one of the sciences, mathematics, or engineering to be considered for admission to an advanced degree program. An undergraduate major in chemistry, with the following courses, is desirable: 1. One year of organic chemistry (lecture and laboratory). 2. One year of calculus-based physical chemistry (lecture and laboratory). 3. One year of analytical chemistry including instrumental analysis. Students with deficiencies in any area may be admitted, but such deficiencies may restrict the research areas available to the student and lead to requirements for additional courses during graduate study. Prospective students are encouraged to contact faculty in areas of the students’ research interest. Applicants are strongly encouraged to submit Graduate Record Examination (GRE) general and chemistry test scores. Foreign students whose native language is not English will be required to obtain at least 550 paper score, 220 computer score, on the Test for English as a Foreign Language (TOEFL). This program requires a nonrefundable $65 application fee that must be submitted with the application for Admissions to Graduate Study in the School of Chemical and Biomolecular Sciences. Applicants must pay this fee by credit card. Placement Examinations During the week before the beginning of classes, each admitted student is given written examinations (ACS standard or equivalent examination) in the five divisions of chemistry: analytical, inorganic, organic, physical, and biochemistry. Every student is required to take at least three exams. The results of these examinations are used to advise the student regarding any deficiencies to be corrected, and to place the student in appropriate courses as determined by a Graduate Student Advisory Committee. Therefore, we strongly encourage and expect all beginning students to review the appropriate undergraduate material before taking these examinations. Failure to pass the exams will generally require that the student take some remedial coursework. 2022-2023 Academic Catalog 2 Introduction to Research Techniques All graduate students must register for CHEM 592, Introduction to Research, during the first fall semester in residence. Minimum Registration All students admitted to the school will register for a minimum of nine credit hours every semester in residence except during the first semester, summer sessions, and while registered for CHEM 601 only. In the first semester, the students must register for a minimum of six credit hours, and in every summer session, a minimum of three credit hours. Registration for less than this requirement is not considered satisfactory progress toward a degree. Formal Course Work Requirement Each student must complete the courses specified by the student’s graduate committee in the program of study. Generally, these will include the courses specified by the student’s major division. The minimum course requirement for students in the master’s and doctoral programs includes at least 21 credit hours of 500-level lecture-style courses and follows a “2+2+3” format, in which all students must take for credit at least two courses (six credit hours) within the student’s major field and at least two courses (six credit hours) from outside the major field. In addition, students must take three lecture-style courses at the 500- level, which must be approved by the Student’s Graduate Committee. These three courses may be within the student’s major division or may be from outside the major field or outside the School. Select 400-level lecture-style courses offered by the School are eligible including CHEM 451A, CHEM 451B, CHEM 456, CHEM 468, and CHEM 479. Eligible courses taken while in the M.S. in Chemistry at SIU may be applied to these program course requirements. For a student working in a cross-divisional area, the committee will design an appropriate program of study in consultation with the Graduate Advisor and the faculty of the divisions involved. Students must receive credit for graded presentations recorded as CHEM 593A-C. Masters and doctoral students are required to receive credit for CHEM 593A, which is a literature presentation that is organized through the student’s divisional journal club. In addition, Ph.D. in Chemistry students must receive credit for CHEM 593B and CHEM 593C, which are received for graded presentations associated with the presentation of an independent research proposal and a presentation of the student’s dissertation research, respectively. All students must take one credit hour of CHEM 597, Professional Training, and one credit hour of CHEM 595A-E, Journal Club, each semester in residence. Research Director and Graduate Committee Selection Each student must select a research director and graduate committee preferably during the first semester, but no later than the end of the second semester in residence. The student must obtain a selection form provided by the graduate adviser and must interview at least four faculty members before selecting a research director and graduate committee. For a M.S. in Chemistry candidate, the committee shall consist of the research director (chair), at least one member of the major division other than the research director, and at least one member outside the major division. For a Ph.D. in Chemistry candidate, the committee is identical except that at least one member outside the School is included. The Director of the School of Chemical and Biomolecular Sciences, if not otherwise appointed, is an ex-officio member of every graduate committee. A division may increase this requirement. Graduate Committee Functions. The functions of the graduate committee are listed below: 1. To plan and approve the student’s program of study. 2. To review the student’s progress in courses and suggest and approve changes in the program of study. 3. To evaluate the student’s progress in research and to make appropriate recommendations. 4. To determine whether a student may continue toward a degree. If continuation is denied, the committee must notify in writing the School Director of the reasons for this denial. 5. To read and evaluate the student’s thesis or dissertation. 6. To conduct required oral examinations. 2022-2023 Academic Catalog 5 CHEM444 - Intermediate Organic Chemistry A transitional course between introductory and graduate level chemistry. The chemistry of carbon compounds based upon a mechanistic approach will be discussed. Three lectures per week. Prerequisite: C- or better in CHEM 340 and 442. Offered fall semester only. Credit Hours: 3 CHEM451A - Biochemistry (Same as BCHM 451A and MBMB 451A) First half of the 451 A,B two semester course. Introduction to structure and function of biomolecules including nucleic acids, proteins, sugars, polysaccharides, lipids and membranes, biochemical techniques, expression of genetic information, signal transduction and transport through membranes. Prerequisites: CHEM 340 and CHEM 342 or 442, or equivalents with grades of C- or better. Credit Hours: 3 CHEM451B - Biochemistry (Same as BCHM 451B and MBMB 451B) Second half of 451A,B two semester course. Basic kinetics, enzyme kinetics, enzyme inhibitors, regulation of enzymes, oxidation- reduction, high energy bonds, carbohydrate metabolism, aerobic/anaerobic metabolism, lipid metabolism, nitrogen metabolism, hormonal control of metabolism. Prerequisite: MBMB 451A or BCHM 451A or CHEM 451A or equivalent with a grade of C- or better. Credit Hours: 3 CHEM456 - Biophysical Chemistry (Same as MBMB 456 and BCHM 456) A one-semester course in Biophysical Chemistry intended for biochemists and molecular biologists. Emphasis will be on solution thermodynamics, kinetics and spectroscopy applied to biological systems. Prerequisites: CHEM 340 and 442, MATH 141 or 150, MBMB 451A or BCHM 451A or CHEM 451A, or equivalents. Credit Hours: 3 CHEM460 - Quantum Mechanics and Spectroscopy An introduction to quantum mechanics and spectroscopy. Prerequisite: MATH 250; C- or better in CHEM 360. MATH 221 or 305 is recommended as prerequisite or concurrent enrollment. Offered spring semester only. Credit Hours: 3 CHEM468 - Application of Symmetry to Chemistry The concepts of symmetry elements, groups and character tables will be taught. Symmetry will be applied to molecules in order to simplify and characterize their wave functions and vibrational frequencies. Prerequisite: C- or better in CHEM 460. Offered spring semester in odd years only. Credit Hours: 3 CHEM479 - Principles of Materials Chemistry Introduction to fundamental concepts of materials chemistry. Synthesis, characterization, processing and applications of different materials including solids, polymers, ceramics and molecularly designed materials. Prerequisite: CHEM 360, 411 or concurrent enrollment. Offered fall semester in odd years only. Credit Hours: 3 CHEM489 - Special Topics in Chemistry Special approval needed from the instructor and director. Credit Hours: 1-3 CHEM506 - Chemistry Topics for Teachers This graduate-level chemistry course covers topics, methods and activities that target the needs of elementary and middle school science teachers. The course consists of a combination of lectures and laboratory experiments. The specific subjects covered during the course change, depending on the needs of the current students. This course may only be taken as part of an approved major. Special approval needed from the instructor. Credit Hours: 3 CHEM511A - Advanced Inorganic Chemistry Principles of group theory and their application to molecular structure, ligand field theory and its application and magnetic properties of matter. Prerequisite: CHEM 360, CHEM 460, and CHEM 411. Credit Hours: 3 CHEM511B - Advanced Inorganic Chemistry Energetics, kinetics and mechanisms of inorganic systems. Prerequisite: CHEM 360, CHEM 411 and CHEM 460. Credit Hours: 3 CHEM519 - Advanced Topics in Inorganic Chemistry Metal ions in biological processes and other selected topics to be announced by the program. Maximum nine credit hours. Special approval needed from the instructor. Credit Hours: 3 CHEM531 - Introduction to Analytical Separations An introduction to the basic principles underlying separation science, with emphasis on all major chromatographies, gel and capillary electrophoresis, isoelectric focusing, field-flow fractionation, rate and isopynic sedimentation, filtration, reverse osmosis and related methods. Prerequisite: MATH 250. Credit Hours: 3 2022-2023 Academic Catalog 6 CHEM532 - Analytical Chemistry Instrumentation Introduction to analog and digital electronics and the computer control of system components. The course will focus on chemical instrumental and the use of filters, amplifiers and digital signal processing to improve sensitivity and detection limits. Two lectures and one three-hour laboratory per week. Prerequisite: CHEM 434. Credit Hours: 3 CHEM533 - Analytical Spectroscopy Fundamental and experimental aspects of electronic and vibrational spectrometry, with a particular emphasis on the spectroscopic analysis of atomic and molecular species. Various sources of electromagnetic radiation, detectors, optical components and the optimization of experimental methods are covered in detail. Common spectroscopic techniques are covered in detail and a portion of the course covers newly emerging techniques and developments. Prerequisite: CHEM 434. Credit Hours: 3 CHEM534 - Electrochemistry Fundamentals and applications of electrochemical methods, with emphasis on the thermodynamics and kinetics of electron transfer, electrode double-layer structures, as well as varied voltammetric techniques. Credit Hours: 3 CHEM535 - Advanced Analytical Chemistry Course surveys various statistical, data-manipulative, and numerical methods as applied to analytical chemistry, including probability distributions, methods of maximum likelihood, linear and nonlinear least squares, correlation coefficients, chi-square, F and T distributions, Pearson statistics, analysis of variance, convolution, deconvolution, cross-correlation, autocorrelation, data acquisition, Nyquist theorem, aliasing, digitization errors, digital filtering, Monte Carlo methods, and finite-difference equations. Prerequisite: CHEM 434. Credit Hours: 3 CHEM536 - Principles of Mass Spectrometry This course is an introduction to mass spectrometry with a focus on pharmaceutical and biological applications. Topics that will be covered include instrument design, ionization techniques, tandem mass spectrometry, chromatography/mass spectrometry and mass spectral interpretation. Prerequisite: CHEM 434. Credit Hours: 3 CHEM537 - Fluorescence Spectroscopy Fundamental and experimental aspects of analytical methods based on the various phenomena of luminescence. General principles of luminescence are covered in detail, as well as analytical techniques based on fluorescence quenching, energy transfer, polarization, and time resolved methods. Aspects of source of electromagnetic radiation, detectors, and electronic/ optical components are discussed specifically as they pertain to fluorescence spectroscopy. Newly emerging fluorescence based techniques are also discussed. Prerequisite: CHEM 434 and CHEM 533 (or consent of the instructor). Credit Hours: 3 CHEM538 - Nanoscale Probing and Imaging This course covers basic principles of scanning probe microscopy and spectroscopy including STM, AFM, ACM and NSOM, and the broad applications in nanoscale probing and imaging. Topics include surface characterization and manipulation, nanolithography, nanomaterials, self-assembly, molecular electronics, optoelectronics, nanoscale electron transfer, single-molecular spectroscopy, protein structures, enzyme dynamics, and living cell imaging. Prerequisite: CHEM 330, CHEM 434, CHEM 360, and CHEM 460. Credit Hours: 3 CHEM539 - Advanced Topics in Analytical Chemistry Selected topics of interest to practicing analytical chemists such as microanalytical chemistry, functional-group chemical determinations, absorption spectroscopy and electroanalytical chemistry. Maximum nine credit hours. Prerequisite: CHEM 434 with a minimum grade of C. Credit Hours: 3 CHEM541 - Organic Structure and Reactivity Structure and reactivity of organic compounds: steric, electronic, kinetic and thermodynamic aspects and their relation to reactive intermediates. Credit Hours: 3 CHEM542 - Mechanistic Organic Chemistry Reaction mechanisms in organic chemistry. Electrocyclic and sigmatropic reactions, cycloadditions, free radicals, photochemistry and organometallic catalysis. Spectroscopic methods. Credit Hours: 3 CHEM543 - Synthetic Organic Chemistry Organic synthesis: classical and modern methods. Credit Hours: 3 CHEM549 - Advanced Topics in Organic Chemistry Specialized topics in organic chemistry. The topic to be covered is announced by the program. Maximum nine credit hours. Prerequisite: CHEM 542. Credit Hours: 3 2022-2023 Academic Catalog 7 CHEM552 - Biomolecular Structure and Function This course will cover the structural basis of biomolecules with an emphasis on the chemical and physical aspects involved in the architecture of proteins and nucleic acids. The study of the physical properties of biomolecular interactions and assembly of biomolecules into macromolecular complexes will be covered. Interpretation of data from atomic resolution techniques will be discussed. Prerequisites: CHEM 350 or CHEM 451A/B or equivalent. Credit Hours: 3 CHEM559 - Advanced Topics in Biological Chemistry Specialized topics in biological chemistry. The topic to be covered is announced by the program. Maximum nine credit hours. Prerequisite: C or better in CHEM 350 or CHEM 451A,B or equivalent. Credit Hours: 3 CHEM560 - Introduction to Quantum Chemistry Basic principles and applications of quantum mechanics to chemistry. Topics include operator and vector algebra, classical mechanics, angular momentum, approximate methods, hydrogen-like atoms and molecular electronic structure. Three lectures per week. Prerequisite: CHEM 360 and CHEM 460. Credit Hours: 3 CHEM561 - Molecular Orbital Theory An introduction to molecular orbital theory. Applications and limitations of various methods. Three lectures per week. Prerequisite: CHEM 360 and CHEM 460. Credit Hours: 3 CHEM562 - Advanced Molecular Spectroscopy Theory of rotational and vibrational spectroscopy, electronic spectroscopy of molecules. Three lectures per week. Prerequisite: CHEM 468 or consent of instructor. Credit Hours: 3 CHEM563 - Computational Chemical and Materials Sciences An introduction to commercial molecular modeling softwares and to performing designed research projects related to chemical and materials sciences. Three lectures per week. Prerequisite: CHEM 360 and CHEM 460 (1 year of undergraduate Physical Chemistry) or consent of instructor. Credit Hours: 3 CHEM564 - Statistical Thermodynamics Principles of statistical mechanics and applications to equilibrium and nonequilibrium systems. Topics include ideal gases, monatomic crystals, lattice statistics, the cluster method, correlation functions, Brownian motion, the Boltzmann equation and the Kubo-Green technique. Three lectures per week. Credit Hours: 3 CHEM569 - Advanced Topics in Physical Chemistry Topic to be announced by the program. Maximum nine credit hours. Special approval needed from the instructor. Credit Hours: 3 CHEM575 - Methods of Materials Characterization An introduction to the structural, morphological, spectroscopic, and thermal characterization techniques commonly used in materials chemistry. Special approval needed from the instructor. Credit Hours: 3 CHEM579 - Topics in Advanced Materials Design and applications of advanced materials. Special topics will focus on contemporary research areas of interest as determined by the instructor. Special approval needed from the instructor. Credit Hours: 3 CHEM592 - Introduction to Research Introduction to the techniques and methods of chemical research including good laboratory practice, research ethics, record keeping, publication, patents and currently active research in this program. Graded S/U only. Credit Hours: 1 CHEM593A - Graded Seminar-Literature Seminar Seminar presentations on advanced topics given in partial fulfillment of the requirements for the MS and PhD degrees in Chemistry. Credit Hours: 1 CHEM593B - Graded Seminar-Independent Proposal Presentation Seminar presentations on advanced topics given in partial fulfillment of the requirements for the MS and PhD degrees in Chemistry. Credit Hours: 1 CHEM593C - Graded Seminar-Research Seminar Seminar presentations on advanced topics given in partial fulfillment of the requirements for the MS and PhD degrees in Chemistry. Credit Hours: 1 CHEM594A - Special Readings in Chemistry Assigned library work in any of these fields of chemistry with individual instruction by a staff member. Analytical. Maximum credit three hours. Credit Hours: 2-3