Conflict of Interest: Classification and Identification in Biomedical Research, Study notes of Business

Download Conflict of Interest: Classification and Identification in Biomedical Research and more Study notes Business in PDF only on Docsity! APPENDICES Appendix 1: Conflict of interest framework Part 1: Classification of conflicts of interest (COI) Financial Professional Intellectual Advocatory Individual Individual Financial Individual Professional Individual Intellectual Institutional Institutional Financial Institutional Advocatory COI can be individual or institutional:  Individual COI arise from relationships established by the individual. Types of individual COI include financial, professional, and intellectual COIs;  Institutional COI arise from relationships established by the individual’s institution, and of which that individual is aware. Types of institutional COI include financial and advocatory COIs. We used the following rules to distinguish between the different types of COI:  Financial COI implies direct benefit, while professional COI implies indirect benefit;  Professional COI implies a clinical activity, while intellectual COI implies a non- clinical activity;  Intellectual COI implies no public statement, while advocatory COI implies a public statement. Part 2: Classification of individual financial COI Definition: Individual financial COI arises from any payment, research funding, consultancy, advisory board membership, and the like from the manufacturer of a drug or device under consideration. This type of COI may involve the individuals themselves, their families or a business they own. Typically, a timeframe of three to five years is considered for these COIs. Grant from source(s) same as funding source(s) Types: grant, salary for research, contract, fellowship, unrestricted educational funding, peer-reviewed grant funding e.g., a paper is funded by AHRQ and an author received a grant from AHRQ, during conduct of the study or when unrelated to the submitted work or when not specified Grant from source(s) different from funding source(s) e.g., a paper is not funded, or a paper is funded by AHRQ, but an author received a grant from Pfizer Employment Types: former employment, current employment, stipend, salary Personal fees (other than Employment) Types: honoraria, royalties, fees for consulting, lectures, speakers’ bureaus, expert testimony, presentations, editorial work, manuscript preparation, trial involvement. management, educational support, production of books, article research, scientific meetings, entertainment, gift, charitable contribution, other affiliations (e.g., advisory board, steering committee membership) Non-monetary support Types: travel paid, writing assistance, administrative support, food and beverage Drug/equipment supplies Patent(s) Stocks, bonds, stock options, other securities (e.g., equity) “Other types” Appendix 2: Search strategies CDSR search strategy for Cochrane Reviews 1. “the” 2. or “methods” 3. or “results” 4. limit to Cochrane reviews and Cochrane Library Online Publication Date between Jan 2015 and Jun 2015 MEDLINE (Ovid interface) search strategy for non-Cochrane Reviews (Filter designed by the Health Information Research Unit of McMaster University, Hamilton, Ontario, Canada) 1. Meta-Analysis as Topic/ 2. meta analy$.tw. 3. metaanaly$.tw. 4. Meta-Analysis/ 5. (systematic adj (review$1 or overview$1)).tw. 6. exp "Review Literature as Topic"/ 7. 3 or 4 or 5 or 6 8. cochrane.ab. 9. embase.ab. 10. (psychlit or psyclit).ab. 11. (psychinfo or psycinfo).ab. 12. (cinahl or cinhal).ab. 13. science citation index.ab. 14. bids.ab. 15. cancerlit.ab. 16. 8 or 9 or 10 or 11 or 12 or 13 or 14 or 15 17. reference list$.ab. 18. bibliograph$.ab. 19. hand-search$.ab. 20. relevant journals.ab. 21. manual search$.ab. 22. 17 or 18 or 19 or 20 or 21 23. selection criteria.ab. 24. data extraction.ab. 25. 23 or 24 26. Review/ 27. 25 and 26 28. Comment/ 29. Letter/ 30. Editorial/ 31. animal/ 32. human/ 33. 31 not (31 and 32) 34. or/28-30,33 35. 7 or 16 or 22 or 27 36. 35 not 34 37. limit 36 to ("core clinical journals (aim)" and yr="2015") Appendix 3: Categories and definitions of the sources of funding Internal funding author is the “Chair of –“; intramural fund; provided by institution, university, hospital affiliation, academic affiliation External funding: 1. Government national, regional (province, county), or governmental body, organization, or association 2. Private for profit drug/device industry or private company 3. Private not for profit with evidence of support by private for profit that is a drug/device industry foundation or organization that receives funding from a drug industry, as stated in information provided online 4. Private not for profit with evidence of support by private for profit that is not a drug/device industry foundation or philanthropy that was founded by billionaires or that receives funding from a private industry that is not known to produce drugs/devices, as stated in information provided online 5. Private not for profit with no evidence of support by private for profit foundation or organization that is not known to receive funding from any governmental or private company, as stated in information provided online