Epoxides: Properties, Preparation, and Reactions, Study notes of Organic Chemistry

Download Epoxides: Properties, Preparation, and Reactions and more Study notes Organic Chemistry in PDF only on Docsity! Epoxides Epoxides O Epoxides are 3-membered rings that contain oxygen. They are very strained and therefore very reactive!! Examples mCPBA O H H mCPBA H3C CH3 O H H Reactions of Epoxides • Acid catalyzed ring opening: O H+, CH3OH H3C O OH O H +, H2O HO OH How does it work? O H+ O H H O H O OHH H HO OH -H+ Reactions of Epoxides • Nucleophilic (source) opening of the ring: O H3C OH O HO C How does it work? O H3C O- H-O-H 1) CH3MgBr 2) H2O 1) Na+ C CH CH Adds 2 carbons! H3C MgBr !" !+ MgBr+ H3C OH 2) H2O