Female Reproductive System - Pathology - Lecture Slides, Slides of Pathology

Download Female Reproductive System - Pathology - Lecture Slides and more Slides Pathology in PDF only on Docsity! Female Reproductive System Docsity.com TOPICS • TODAY (Part I) – Vulva – Vagina – Cervix, uterus – Body, uterus – Tubes • NEXT CLASS (Part II) – Ovaries – Placenta Docsity.com The types of lichen lesions which show HYPER-plastic mucosal changes are often regarded as being potentially pre-malignant Docsity.com VIN, SCC • Like condylomas, HIGHLY linked to HPV • VIN=changes leading to SCC-in- situ, look like “plaques” • BEYOND VIN = INFILTRATION Docsity.com VAGINA • CONGENITAL: Parallel uterus anomalies • INFLAMMATORY – PRE-menopausal: STD – POST-menopausal: ATROPHY • BENIGN: Hidradenoma, Condyloma • MALIGNANT: VIN, INFILTRATING SCC Docsity.com VAGINAL NEOPLASIA • VIN • INFILTRATING SCC • ADENOSIS (D.E.S.)  • ADENOCARCINOMA (Di- Ethyl-Stilbestrol) Docsity.com CERVIX • NORMAL • METAPLASIA • INFLAMMATION • POLYPS • DYSPLASIA • CIN • INFILTRATING SCC Docsity.com ENDOMETRIUM • FUNCTIONAL HISTOLOGY • D.U.B. (Dysfunctional Uterine Bleeding) • INFLAMMATION • ADENOMYOSIS/ENDOMETRIOSIS • POLYPS/HYPERPLASIA • ADENOCARCINOMA and/or STROMAL • LEIOMYOMYOMAS, -SARCOMAS • MITOSES differentiate benign from malignant Docsity.com ENDOMETRIOSIS Defined as normal endometrial glands OUTSIDE the confines of the myometrium Reverse menstruation vs. Embryologic “rest” theories EXTREMELY common cause of cyclical abdominal/pelvic pain Broad Ligament, Ovary (“chocolate cysts”), Peritoneum, Bowel, Umbilicus Docsity.com ADENOCARCINOMA of the ENDOMETRIUM • Papillary, Polypoid • Clear Cell • Adeno-Squamous • Mucinous • Serous • Preceded by hyperplasia, dysplasia (EIN) • Estrogenic, DES effects • Ass. w.: obesity, diabetes, hypertension, infertility • Stromal “sarcomatous” conditions can co-exist, i.e., “adenosarcoma” Docsity.com GRADING and STAGING • GRADING – 1, 2, 3 – Well, Moderate, Poor • STAGING – (I) Corpus – (II) Corpus + Cervix – (III) Beyond uterus, but inside true pelvis – (IV) Outside true pelvis or involving bladder or rectal mucosa Docsity.com