Genome Organization in Bacteria - Lecture Slides | BIOL 7023, Study notes of Biology

Download Genome Organization in Bacteria - Lecture Slides | BIOL 7023 and more Study notes Biology in PDF only on Docsity! Genome Organization in Bacteria By Steven Salzberg Manjula Kasoji 11/19/07 Topics • The factors involved in shaping genome organization and evolution in bacteria. • Non-coding DNA plays an important role in encoding for regulatory signals. • TransTermHP • OperonDB • Overlapping genes OperonDB • The algorithm takes into account alternative possibilities: – functionally unrelated genes may have the same order due simply because they were adjacent in a common ancestor. – genes may be adjacent in two genomes by chance alone, or due to horizontal transfer of the gene pair. Overlapping genes • Very common in bacteria. • Over 30% of genes overlap • Model to explain the pattern (3 types) – Unified model – Patterns are non-uniform in their distribution