Download Hematologie-Leucemiile acute and more Summaries Hematology in PDF only on Docsity! Leucemia acutamieloida Tabloul clivia : Debut rapid , * sez Pa medic in decursul a cateve zile pacientieEbetur rimpt .Poate debutael, byupa pica, taus, S Iinapetenti T aespecial s rai edi secdere sauderda, e e O , S · out de de paretoponic : IPrincipalels warif ↑ Anemie-> astacie psica, dispues , awetli , expecte& ecti recedeH brateneopenie -> Iif , fe 3) trombecitoponic--Ipefesi , gingivaagii, spistaxis . Explorari paraclivice : I. Teste diagnostics & prognostice : 1 . HLf : - birito,Asirsou pareitope a 1 Hl C !↓ stast ve apara , arepoweraleemiespotr 2 . wadelagrawa : -infiltrat blastic modular -20% privMudie aspiratioawar is al aspiratulas mudular si protivler3. dog el' :souge pero sing eu I-diainlanI 5. examen flaveitomatic (immnoperatipia : s f His aspirat900 modular si stabilegte en certitudiese aparteeefa la livawieloid . "Markeri de linie mieloid sunt CD33 , CD117 , MPOc · s . avousers eitogenetic : opera informati prognostice ↑ S It10il i + (15, 17) ; inv . Is-prognostic favorabil - . xaudreau miboila - mutati ale TP53 si ASXL1 : prognostic refavorabil& iTests carr evalueaza startunl biologi al pacientelei.in Alte tests (ex : test o Carcino & la I- ete .) evei in perivadafertila, Diag fie positiv :Nos a n . de LA estein fo soutdivcoupa ecomple er &major de diag ⑧Testele citoenzimation n in secial immnoferot para , dra·bilesapartemente poli at 9 e la livia micloida. ↳sentiale in topunatic ene biologie molecular mutinli si a conduitei terapeutice . prognost / Principi de hatament: comorbiditati se jea hatausustLa soscienti Liveri fara appcrativ , iar la cei in vorsta 160-Gravil ce prezinta comorb. se ineppe batourful paleativ Diagu . poz : ca la LAM Princip de tratament : ↑ Inducers revision complete : en articoterapist o autacidline- Wincristine' - pf. par . Put : chimioterapie + inh . de tirzininaza (po fineri an ind. do allotouplant in primar ruisine coupletal ; trapia o mentvere dupa/LKausplant en inh. de T este secon . pt . a perivade de 12 au. - monitoritarea resp. Le that , so face prive monitBCR-ABL · SNC ev ind de iradiereI Profilaxia SNC : -par - w aftotala' cerebrale (diagn . se face priv publicCambara') in Terapia de consolidare : - La sacienti Ph- , BMR-, standard risk : adm . o eure citostrative 'ne doze mari , 4-1 cicluri , an epicirutes asupra afectori SNC & ti tincri , high risk , BMR- , Ph-se indicaLa sacier allations , 2 serifericaslaut a calule stew I3) La scienti standard s cow risk , dar BMR + ST slaut . recoualuda cellations ,4) Pacienti en BMR+ an recordan de obtivera I rogativMafausplautenter & - "Terapie de metivers : - - seadreseaza pac. car we not eligibili pt . alloemplat scale obtive resp . Molocular complet (DMR-1 . 1-se continua 2-3 on dupo obtiverse rasp cuplet↓ consta in ad de Metahexat' saptoimonal i Purivetholfiluic . 3 besu ar renoluerra risii a- he fix cate sofvincristica o zi s Prednison szile
