Download Immune System - Principles of Biology I - Lecture Notes | BIOL 1107 and more Study notes Biology in PDF only on Docsity! immune system 12/11/2009 Pathogens Barriers help an animal to defend itself from the many dangerous pathogens it may encounter Immune system Recognizes foreign bodies and responds with the production of immune cells and proteins Two defense systems innate immunity acquired immunity o dictates anything involved with the system needs to be capable of determining whether something is a foreign substance o more sophisticated foreign substances are called antigens o slower initially than an innate response o *difference between humoral and innate response o humoral antibodies o cell mediated involves cell line acquired immunity broken down o vertebrates have acquired b/c this there are autoimmune diseases innate immunity broken down blood typing A has A antigens and B antibodies B has B antigens and A antibodies RH+ has a protein O no antigens, A and B antibodies o O goes into every one b/c has no antigens o A have immunoglobulin(antibodies) against B proteins Lymphatic system Moves to lymphatic system as well as blood and interstitial fluid Innate system Cells move between blood and interstitial fluid Immunocompentancy(know word) o Lymph nodes B cells- gain competency in bone marrow T cell is from thymus B cells are from Bursa tissue o Which are protective sacs in joints Fever Designed to provide an environments to where the environment is not conducive to bacteria cells All cells in the body (except red blood cells) have a class 1 MHC protein on their surface Cancerous or infected cells no longer express this protein; NATURAL KILLER(NK) cells attack these damaged cells, all b/c denatured or lost class one protein Lumphocytes White blood cells o Recognize and respond to antigens, foreign molecules Acquired leukocytes You have to teach B and T cells what to “kill” Most are destroyed before release from bone marrow and thymus Our body in thymus and bone marrow have cells that determined whether cells know self or non self, if not learned killed before reach system. The rest move out killing cell mediated response o Auto immune disease don’t know self from non self, escape into body and begin to dismantle systems within the body. Helper T cells Killed by HIV
