Download Wound Healing and Blood Clotting: Terms, Definitions, and Processes and more Quizzes Engineering in PDF only on Docsity! TERM 1 response to tissue injury DEFINITION 1 **necrosis,**apoptosis,**atrophy(decrease in cell size and/or function),**hypertrophy(increase in cell size)**hyperplasia(increase in cell number),**Metaplasia(change in cell type),** change in phenotype (change in the type and/or amount of protein characteristic of a particular cell type) TERM 2 what tissues have a high capacity to heal DEFINITION 2 epithelial, lymphoid, hymatopoietic, mesenchymal tissues, and highly vascularized TERM 3 what tissues have a low capacity to heal DEFINITION 3 Nerve, muscle, and cartilage TERM 4 how does age affect wound healing DEFINITION 4 slows it and increases scarring TERM 5 what factors affect the rate of healing DEFINITION 5 size of wound, amount of contamination, degree of vascularization, presence of a foreign body, general health of patient, and age TERM 6 sequence of events following device implantation DEFINITION 6 **injury, **acute inflammation,**chronic inflammation, **granulation tissue,** foreign body reaction, 8*fibrous encapsulation TERM 7 hemostasis DEFINITION 7 process of blood clotting and then the subsequent dissolution of the clot, following repair of the injured tissue, composed of 4 steps TERM 8 step 1 hemostasis DEFINITION 8 vascular constriction. limits the flow of blood to the area of injury TERM 9 step 2 hemostasis DEFINITION 9 platelets become activated by thrombin and aggregate at the site of injury, forming a temporary,loose platelet plug. The protein fibrinogen is primarily responsible for stimulating platelet clumping. Platelets clump by binding to collagen that becomes exposed following rupture of the endothelial lining of vessels **Note:upon activation, platelets release ADP and TXA2. serotonin, phospholipids, lipoproteins, this is important for the coagulation cascade. in addition activated platelets change their shape to accommodate the formation of the plug. TERM 10 step 3 hemostasis DEFINITION 10 to insure stability of the initially loose platelet plug, a fibrin mesh (clot) forms and entraps the plug TERM 1 response to tissue injury DEFINITION 1 **necrosis,**apoptosis,**atrophy(decrease in cell size and/or function),**hypertrophy(increase in cell size)**hyperplasia(increase in cell number),**Metaplasia(change in cell type),** change in phenotype (change in the type and/or amount of protein characteristic of a particular cell type) TERM 2 what tissues have a high capacity to heal DEFINITION 2 epithelial, lymphoid, hymatopoietic, mesenchymal tissues, and highly vascularized TERM 3 what tissues have a low capacity to heal DEFINITION 3 Nerve, muscle, and cartilage TERM 4 how does age affect wound healing DEFINITION 4 slows it and increases scarring TERM 5 what factors affect the rate of healing DEFINITION 5 size of wound, amount of contamination, degree of vascularization, presence of a foreign body, general health of patient, and age TERM 6 sequence of events following device implantation DEFINITION 6 **injury, **acute inflammation,**chronic inflammation, **granulation tissue,** foreign body reaction, 8*fibrous encapsulation TERM 7 hemostasis DEFINITION 7 process of blood clotting and then the subsequent dissolution of the clot, following repair of the injured tissue, composed of 4 steps TERM 8 step 1 hemostasis DEFINITION 8 vascular constriction. limits the flow of blood to the area of injury TERM 9 step 2 hemostasis DEFINITION 9 platelets become activated by thrombin and aggregate at the site of injury, forming a temporary,loose platelet plug. The protein fibrinogen is primarily responsible for stimulating platelet clumping. Platelets clump by binding to collagen that becomes exposed following rupture of the endothelial lining of vessels **Note:upon activation, platelets release ADP and TXA2. serotonin, phospholipids, lipoproteins, this is important for the coagulation cascade. in addition activated platelets change their shape to accommodate the formation of the plug. TERM 10 step 3 hemostasis DEFINITION 10 to insure stability of the initially loose platelet plug, a fibrin mesh (clot) forms and entraps the plug TERM 21 TGF-b DEFINITION 21 chemoattractant for monocytes and fibroblasts **pro- fibrogenic --stimulates fibroblast proliferation --stimulates fibroblasts to secrete matrix and therefore aids in the development of wound strength --stimulates angiogenesis (new blood vessel development) TERM 22 granulocyte DEFINITION 22 any blood cell containing specific granules TERM 23 leukocyte DEFINITION 23 colorless blood cell capable of ameboid movement TERM 24 macrophage DEFINITION 24 large phagocytic mononuclear cell TERM 25 hematocrit DEFINITION 25 % of the total blood volume that is occupied by packed red blood cells TERM 26 hemoglobin DEFINITION 26 content of erythrocytes, measured as total Hb content of blood TERM 27 why is mean red cell volume important DEFINITION 27 MCV, due to disease blood cell may undergo size change TERM 28 what are the units of red cell count DEFINITION 28 counted in millions of cells per microliter TERM 29 why is the morphology of red blood cells important DEFINITION 29 disease may cause cell to change shape TERM 30 total white cell count DEFINITION 30 tells the total number of all types of white blood cells TERM 31 differential white cell count DEFINITION 31 estimates the relative numbers of the five types of white cells. TERM 32 why is platelet count helpful DEFINITION 32 suggestive of the ability of the blood to clot TERM 33 clinical signs of inflammation DEFINITION 33 redness(rubor), swelling (tumor), pain (dolor), heat (calor) TERM 34 what causes the redness in inflammation DEFINITION 34 high number of red blood cells close to surface TERM 35 what causes swelling in inflammation DEFINITION 35 permeability**pressure difference between capillary and external tissue bed,**endothelium is tight permits very slow flow of water and small molecules into surrounding tissue normally the lymphatic vessesls drain away excess fluid
