Download Lecture Slides on Introduction to Bioinformatics | BSC 5936 and more Study notes Biology in PDF only on Docsity! BSC5936 Intro. Bioinformatics 1/16/2003 (c) Michael S. Chapman 1 1/16/2003 Course BSC5936: Topic (c) M.S.Chapman 1 BSC5936 Introduction to Bioinformatics Introduction! 1/16/2003 Course BSC5936: Topic (c) M.S.Chapman 2 BioInformatics is the study of… Structure of Biological information & use of the information to infer: Evolutionary systematics Gene structure; How many; distribution; coding vs. non-coding… control; Regulation Molecular structure Function of (hypothetical) gene products Annotation 1/16/2003 Course BSC5936: Topic (c) M.S.Chapman 3 Bioinformatics brings together Large databases of biological information Computational Techniques of analysis Databases Sequence (1D) Genome projects Human, mouse, fruit-fly, slime-mould, pea, rice… – many others 120,000 protein sequences 2003; minimally-redundant; Swiss-Prot Molecular Structure (3D) 20,000 structures, PDB 1/16/2003 Course BSC5936: Topic (c) M.S.Chapman 4 What is it good for? Academic Examples… How many genes are there? Initiation / termination motifs Comparative analyses Mouse genome revealed 1,200 more human genes How many copies of each gene? What is their diversity? When expressed? (micro-array+sequence data) What does the gene do? Homology; Searching for sequence motifs; Structural motifs following 3D prediction 1/16/2003 Course BSC5936: Topic (c) M.S.Chapman 5 Scientific/Technical Applications Molecular Biology: Primers; restriction sites; splicing sites… Sequencing: Coding regions; open-reading frames… Localization; Assays Hybridization markers… Expression; localization Localization signal sequences… 1/16/2003 Course BSC5936: Topic (c) M.S.Chapman 6 Future Applications - Medical Genetic diseases: Cystic fibrosis; Breast Cancer… Screening Gene Therapy? Designer medicine – individualized treatments Drugs – new targets
