novel drug delivery system, Study notes of Biopharmaceutics and Pharmacokinetics

Download novel drug delivery system and more Study notes Biopharmaceutics and Pharmacokinetics in PDF only on Docsity! 2 we — | Novel Dug Debiveauy System —> wear “ae Neo agals Shih WS tagethon atten tho buysielogy fuem ont place ae) | epdoay, te anothan | ——~|"NDDS nrelieure to" The appersaches » foumuLatien technolegres 8 ——~| Syskem feu tuanspeading ofa phaumacauticall compound sn body: ——Tas nodded ts Sajgby and achieve Aosiund Homapeutic ebipcts °7 —— ex— mieus~ emulsion, priyrezomes (aipeseme), tansdumal | Fromapeutic System, PRoLMcesen Zs . conven / Contuslled Dawg Delivers Systin > contiretled dawg : ‘delivemy System aue conceived 2 creloade Aung inceriiiidled manne oveu ime. Desiring of dug dolivesuy aysiem. to dolivers tho douuge at puedotesimined «TCL dl 5 “Trada tp oeductton inside elect andBetterr Patient cemblaines te lug thouwapy,. Thhuodudion > — Conventional dung dalivenny Systoe Trolude Tab. , cap, inf. ,Syar , coos , aannsols have beon used Rum dong Bie and sti) tn use fou treatment: of vartisus diecose Howeveu, Wese pacpoaiation Cconvenktonal desage) aditinisteued PAGE | 4 classmate. ————= pare LL | ; a | ; ohfeh rreuy.- Rood - fuchiottion 4 ae eae Se gaa 4 RAG] deel ae ul ° Reason betiindl hha davcbobrmE NDDS~* eee a Saatatned wale doug bong Hit ED ai ee ° “auget action — CONCOLLDUS Col. al Conventional catage (pur = Pepa IR, te — | * aja eae dig day pro 3 | lc ae ur ele en es Seed fe ele ede OU sages | 2 Luccitmont. ras @| Ta dang should be aslopsad bu Adlvenad dt dis Salinaiad Bila op a oh elton ts Faget mOX - et renee es | } : Avoid Semanal anwarted aay Wa | [© Taco Bian 5 0 Trtemachon inn aap a 7 AEB ge telassmate PAGE al [|  pare TLS ILI III peur 3 > dug ¢ Aged net nelease Immedsadedsy att eo adriiniatsabs ~ eniniis coated capi se a pyrouiiucelt | Ralienale Confallad, Dow Delivery Syatim Tho basic auationale 9}, Coritiantind 1000020 sits, dadivorry - y— | Sysiern 1s. “To eplimize dhe brophasmacenics 5 Phosumacoenah + phaomarody namics peropenibes © f dung hye ee Ww 2 | To maximized the wtilPzaiien thovough meduon tn sido ope and centnetled of disease in shoettest time oe 2| To minimize dung degeedalien and Lose, 1o prevent aoumbul gide effect “dad tiaiiaaa doug bioanatlayiity. (au ene aaa accumulated. dn, Hn Mequote and dostued geno." | e| Conventional desage Foun Cum ko achPeve plasma Ag. lent. dying vottfutn the thenaperttic wendous And mosain — duunotion &f Howapy. >] Hone, Corbnerdod cdeug li dad Sead diy dalibeny systen- v igs of 005 \se aye OH — of duwuga - wen ~ ne A8ed bachent compliance . ey) Ti Paduation, eh dnug Loved in Goad —1|Tolal dag dosage usage te Loss ne a ap f | uy Bysienp: E ~—__*| Gnhanced: the Beawailobly aa classmate. pace [S|] | |  clewig that get acer pou tugh petant doug Reduction SC Cost cin Pocclh Cote Lenn . stm exhibtt dal ‘onset aclipn tible -tp Prorat pass motabstisnn . : _ ge helm ad justime rf feud on eertoirere-eitain C0353; —— *{ These cyst ans areladioa expensive than cpnventiang) ~~ 2] Some ating ean nat joumulatod Snip extend dezage form, ~—— e | teeu ineive and dnbiew Cormlelations - MU - ih Deledlion of Dawg Candilites } — [Adctail trovetedge of AbMe chanaceuialics @ dean & Geotkal— [ vin design Cf contr olded or eloase bereduct - a - | coitenia to Ro mot by doug puepesed Lp Ro foumulaad % -— | CRDF atte follouse > fae ro te | fatrologiale sh Route bf bof = (Giteuiay—_ aantnisinatien “ABocl voliMcuscasy op Faiond sictetog Tunatien of Hatmapiy 4 | R, He3 of Douig. > ‘Sedubility, Pasbitton Coftictent , Btobilty » : t “aE ‘Hereperties OP duu howe to-dn Stucletl” - foqass 5 ivitng fe i i 42 Yep CRS Ccont tod mat 3 7 4 Ie dliminationfodh-Qpe + thorwapoubic ‘ndox : uel natin oo @ extenanse: 45 Pass mebabekceen: PAGE “plreematie  pare [TET LT 4 a > Tio orwuils ogadniutis techn Cound, teranectosumad , Prdoaubeosieny inthe eckablo, mucpoadhosive ,ete ‘} >| deetded tp agteat . Stuctying ¢ enoronic adminiglutioe | das. cand = 5 : e aotodur LO Delabet elabebtc peda ; Trae au aang as Pana a — fal — Sheuld be Studied. 3, | | | | Duuation sf treuaby > “The designing of dobives ayatern i based on dusiation fou whith tt & “Se b9 plored wn bods . acute = > Chareniie >. Implantokin seq. Pou Lortloretlod doliiven a] Er ale Give dufail about tong HEU - ! seum _toxidty perofile- a | Pathelogical , changes Associdlad withdiseaze— | Pathogens can murants evn nuclestida—> vada “Rp inefirdtive ~| Me design. of dds algo dopends on. pathelog toad onanges that | con Place tn Diseue. ~ [Those murtockion may be ettheet berneftetal ou complicated - 4, 8-| Patéent srelasod edu > sodeudl Pachous Buch aS, variation gn GL T matiities deqoten shorisa mersemed in potient » fgg.» weg, ele. ° locherucal Pout Sellachion ef CDDS > molecudan ut—- Qo3athan 600D0alion fq. solubility — 1-2 Olmg /ml — pH — 110 #8 fautition cobfeclent = 1-2 ' ‘ naer Fal T 1 t ;__| ; pare C TIC ICCT 4 —_ 0) Mattitx, davices > Tho doug mekoe ule dispenesed Br /usithin a i —Spetiyeno0i « netiwecdk . a > “ —_— mo _ ee | | Redeassty op pduung 3 tn. phases and thous Thesapeutie oooh > Me crate aA doug dteleaae can-be exbleiinad boy oe Higuehis e es = . 7 fates =_[ dacs |% | d- bung Ghugion ciidenE ~__ > Uy Seif Lreleasel At | xt & ~ Total dmeunt of doug — tive Cs = peng solubility dn Bediyron— Uv Advarttiqas, > © Pusvide betient and gaeaten bipcormpalibilth, due ar = sto igh watea content - ‘ ae Gasiexr te feoduce #han deseevyotu dovTcon . = © | Highmoeelar weight comPeund can de easily dalfoeued . he + e Disadvantages > zeus Suden eloase can’t be achieved. s @ ISSOLUTION CONTROLLED Release > peed Dissolution ts He pieces se ushich QO substan, [Petar a bolution: 4 pisselution corliellad Relooas dystem—> _ ewigs aie cooled wsith GoRustyy dissoWsiing polymeric membralt rete. ons Be — as =H ont SNe ——) ee Stn ie we ete ole <: 3 1 Slousty digseguing sit - High a eke dug peoedy dekuble salt Noyesand wsftiiney — Rlsesiute PAGE |  | equatien expuess *Re aitusiion ciate . dM = os (q-a) D~ Diftusien Gob ideny Gt S- Suahaco direq Cs- Setubility 2 Said a- Conc. Of Sehid JN SALSA | ee Types of dissolution cemtuotlod Release system —> anddoidsval aug Pouticles ea granules woth a Slousty clisselsing maxeuial - v | | el Encabsulatad [Res eoweia, type > TRS Syslemn inoeloes ¢ Coating of | | Coen tieeaee the Cediod fouticlss inte pellcng qfeumohen and | 5 a —__ we > 6 adsninist, [| baulg ceatting with. Compuesseq Capsule Lt tate petynidoy an betas | { ex eniiut Sustand TD Cealed Gpsulemelzase | , 4)| Maleux > (cabeaia /eussion) Sysent >< This System Snyolues tro Comp aeasfon™~ ef sloolu digs siving | casuugen “En toblel Poaumulaiiion. | | | tz —trcrapines® Setuent #S: ag Tesla fasolet Soe Alssetuing Pekymeoe Ths dung Con be contiolled \sia — * alteuing Hu poseeity of, tabld. ° Decwasing Hu werablity of tablet ‘ita dissolving ‘ad ‘Blousea ae Piao plea Plena extent  eHod >. Tes = stem iS designed de puoddy oe ate @€t lonizab xchange Resing 4 - Angebote > Ton ELL ge Hii sl ton a Se a tenibiaks boocken a 2 tation — > == a > HO ee Ee 5 {or 3 : = kymoe Anion = ie Exchange bf, fon wolthin, ding mote 0 , Ee “These palymeo. Certain Salt -ppearing an eS Mebeatting besitien . r ~ Brat qaaup Ey —— Reaint pong” + ions an GLT ees Sy i Regin.- X77 +4 =, = beg —>- - a4 : = 4. Calin exohatge mejion > Tia conta Sata - ie lf _ Calton fiom Aaiuecounding baste AButOn af Dougt gesin~-+ x” ——— > Resin xt +00 yt — cation a.| Arist ex a Reda? Wits. wntain Basle functional quoup Pott Prose the. asulity fo wameve ong qian ATCA Sotutten .! : 4 buwg Rosin + Y7 = Sain Fa : anise classmate PAGE  = <= pate T ILLICIT I felenie deg tase High past ihion cofpictertt value 22 wellaglowe | We ET Sts alue — not suitapte _fou ends. i Ly —> Denia Should oremain Stable al haat Leach thoi dthe oh absouption IN Hee Body - bath acid | base “hydurtyaia Om enerymabic a aalion.. b Sherefote, studying tutu Baty 55 iret ushiile Sesigning We cops. —e | ; Sr: Deugs knot Tindeigpes g ur wall metabetiem and shous - | ing radii, in small U5 vattna ame nex Surtablo feu pbs. — ex= ~ Thufebental pritipyerin. | | | re Absoubed my Comet, aoa tease purocess | Ui CGuucete VIFB | | ped »~ foeu Condiolatos feu epps. [at wis [Rou of ititataaBion, > omal, Pauentenal and tmansdexumot | Hout 1 faust Papieued eat, o| Poupterr’ lotnding of doug > wd | Tad Deng» puna binding dm = = recreate of DP in 1 ly hoe Sr ‘pustongid ostten. of. dius  «| Biological Povepeo — | untpecem tvel sald incorripicle abgouphon, | Casesvotl algo ateault tn deqiring ot cons ae | | ex— Pilecauhine Cabseub only tr Lows eximF 5. Des “Doug with tellous Camiiren med fatad Awangpeeg | net Sultable fete cDbs. °} Distutbutien > The distutbution of doug in te weestows and extra peu Vazeulan. space in body. ; Le a an Smbeodand focloe, UN cts eveuolL cumination Rinekicg Rate OoBou tha cone Umitting Step ef _- | This mouy spunea Fh peat wer dog a Sustain Uelease, podrmarily oy Hestul Hho mogeutude of duelease nate and dese size. i a =| Appamenk velume wf ef dung gives an exact eattmalien Steg dsbsiion. : = +4 v VdSS = f én + Kai) | vp | Kay J °] Metaboli —> Doug Metabslism can wosull ah amie [ed Hhachvalien df active doug ox conyeuster of | fnactive dowa to an adie rmetabslifies. U classmate. PAGE  -[ Te dutug should net be metabolised inte Ue Enactive {oom befose fea Zite ep acion. x q metabelicm sohich Signifgcanily aggect tre ef duug te induce ea tahibel enzyme aynitesis uper ed Augage ‘ | x= Nituegly coaitne , levedepa , ete. | —e| Dunation aAdien—> Dumalien oAdtion t& usually a dundisr Oh Dietegical Nawh Libs - Dowgs Loith Sheet raf Qos ane cesiqnad incite ¢ODS.— osu candidate Pee CDDS.+ Vex Penicillin , cebhalespoins - Dawgs vith Rengeu Folf > —» also net Suttable $94 tdPs ex— Dicuumiansl, Prazepam, Digilexin , Phanywen , Loos aut - A sidockbeds 3 side effect of, dasa exhubet clabemd uperL Cenc. th plagzma, doge , etc. = CDbDS maintain the blaama cent. wf dou - perpyioling advortageous on side effect - ~ | foun ‘dees Show agghegahen of undesirable effect cohan inte CDDS- ex Parrecniselon . ~| Reno dauug does nef shou any exespomee epamble — chioebhensxamin- et Decal and Syatomic 2ido effect of lung Lan be wiimized Soy suttable SncDDS. Yi ) rer - | Reka ef? Aisease Bale and drca.dian Rhy tim > orig am nofa paud of dung powpertttes- U UW classmate. PAGE | (+