NR 565 MIDTERM REVIEW LATEST UPDATED 2024 TOP RATED EXAM STUDY GUIDE FOR GUARANTEED SUCCES, Exams of Nursing

Download NR 565 MIDTERM REVIEW LATEST UPDATED 2024 TOP RATED EXAM STUDY GUIDE FOR GUARANTEED SUCCES and more Exams Nursing in PDF only on Docsity! NR 565 MIDTERM REVIEW LATEST UPDATED 2024 TOP RATED EXAM STUDY GUIDE FOR GUARANTEED SUCCESS. NR 565 MidTerm Review 1. G-Protien coupled receptors and how they interact with drugs G-protein coupled receptors (GPCR) interact with drugs through 7 regions of proteins that span and innervate the cell membrane, and trap the molecule into the receptor site like an interwoven basket (Insel & Sriram, 2018). Drugs can then enter this space and interact with the GRCP. A specific interaction and binding with a site on one or more of the regions of proteins within the GPCR, and drugs bound with the GRCP can stimulate the release of G proteins that can interact with various effector proteins to create physiological responses within the body (Insel & Sriram, 2018). This process occurs through secondary messengers (such as cAMP) which creates the extracellular interactions produced by the drug binding to the GRCP. 2. What neurotransmitters are excitatory? amino acids such as glycine, aspartate, and glutamate are excitatory (Woo & Robinson, p.16, 2016). 3. Which is the most common CYP enzyme in the body? What role does it play? According to the textbook, the CYP3A4 is the most important enzyme in the body. CYP3A4 is responsible for the metabolism of more than 50% of medications and is considered a major drug metabolizing enzyme. CYP3A4 can be found in the liver, as well as the lining of the GI tract. Due to this location, food can also influence this CYP. One example of this is grapefruit juice, which can inhibit CYP3A4. Medications that are metabolized by CYP3A4 include antimicrobials, calcium channel blockers, antihistamines, anticonvulsants, azole antifungals, and corticosteroids (Woo, & Robinson, 2016). 4. What is the clinical significance of being an ultra-rapid CYP2D6 metabolizer? People who are ultra-rapid metabolizers have high activity of CYP2D6 enzymes that break down certain medicines rapidly and are likely to need different doses or even a different medicine. Drug dose, response, and toxicity risk of beta-blockers, antidepressants, antiarrhythmics, and opioid analgesics are dependent on CYP2D6 pharmacogenetics (Ayazseven et al., 2020). Knowing the result of the CYP2D6 test and which group the patient falls into such as poor metabolizers, intermediate metabolizers, or ultra-rapid metabolizers, will help nurse practitioners prescribe the right medication and dosage for the patient. 5. What would be the concern if a drug is a CYP450indicer? How that might NR 565 MIDTERM REVIEW LATEST UPDATED 2024 TOP RATED EXAM STUDY GUIDE FOR GUARANTEED SUCCESS. affect the metabolism of other drug the patient is taking? Cytochrome P450 enzymes are in cells throughout the body, primarily found in liver cells (Girvan & Munro, 2016). These enzymes are essential for the metabolism of many medications. Cytochrome P450 enzymes can act as an inducer or inhibitor of metabolism. When a medication induces the CYP450 enzyme that increases the rate of NR 565 MIDTERM REVIEW LATEST UPDATED 2024 TOP RATED EXAM STUDY GUIDE FOR GUARANTEED SUCCESS. 12. Phase I and II metabolism Phase I metabolism involves non-synthetic reactions. Oxidation, reduction, and hydrolysis reactions prepare molecules for further metabolic reactions. Metabolites are rapidly eliminated during this phase. Remaining metabolites continue onto phase II reactions. This is the synthetic or conjugation reactions. During this phase, molecules are metabolized and another molecule, such as glucuronic acid, glycine, sulfate, or acetate is added to become a compound. This allows the kidneys to secrete the molecules easily because they become more water soluble. 13. What is the significance of VCORC1 mutation? The significance of the VCORC1 mutation is that it is related to an individual exhibiting warfarin resistance since it plays a role in metabolizing the drug warfarin (Woo et al., 2016). This means that the individual is prone to an increased risk of bleeding which can lead to adverse outcomes for the individuals who exhibit this genetic mutation (Fereidouni et al., 2019). The VCORC1 mutation is responsible for producing a “subunit of the vitamin K epoxide reductase complex” (Woo et al., 2016). It is currently not required by the FDA to complete genetic testing prior to starting warfarin, but as practitioners we should encourage our patients to complete genetic testing so that we can accurately calculate the correct dosage for warfarin without creating significant adverse outcomes for these individuals. 14. Can you describe how new drugs are developed from the text? New drugs are developed by researches in a lab first by looking into disease processes and the medications that are used to help treat these disease processes. After looking at the medications to help treat disease better, researches look into how to make the medications be more effective with less toxicity or 'side effects'. in order to do this, researchers start preclinical research. During this phase researchers look into whether the drug is going to kill people or cause serious harm to people. then they go into the clinical phase. The clinical phase is where they use the preclinical phase data and come up with human research subjects. These usually consist of two groups (one getting the new medication and one getting a 'fake' medication (placebo). Then this leads to step 4 the FDA drug review where they come up with labels, safety updates, etc. Then they move on to the post market monitoring where they actually pay attention to the way the medication is being used and what for. (US Food and Drug Administration, 2018) 15. Explain what it means if a drug is an antagonist? An antagonist according to our text is a drug that takes over a receptor without stimulating that receptor. We see the medication blocking the response of an agonist to that receptor. Such as seen in a beta-blocker keeping the adrenergic nerve activity from increasing the heart rate and therefore able to help decrease the heart rate of the patient taking the medication. Antagonists can make the agonist appear less potent. The effect of the antagonist depends on that of the affinity for the receptor and the blood levels noted in the patient (Woo RN PhD ARNP CPNP-PC CNL FAANP, Teri Moser et NR 565 MIDTERM REVIEW LATEST UPDATED 2024 TOP RATED EXAM STUDY GUIDE FOR GUARANTEED SUCCESS. al., 2015). NR 565 MIDTERM REVIEW LATEST UPDATED 2024 TOP RATED EXAM STUDY GUIDE FOR GUARANTEED SUCCESS. Another example would be naltrexone. This medication is used in patients that want to not relapse in heroin or opioid usage. The medication blocks the receptors for the opioids and does not allow the drugs to connect to the receptors. The problem with this is that it can cause an overdose if there is a relapse (Pharmacological Treatment | Medication Assisted Recovery, n.d.). 16. What the terms efficacy and bioavailability mean? According to Woo & Robinson (2016), efficacy in medicine means the power of producing the maximum effect of a drug (Woo & Robinson, 2016, p. 14). When thinking about efficacy and medication, an example may include hypertension medication and how it lowers blood pressure but can also have an effect on other mechanisms in the body such as heart rate or kidney function. Patients who are prescribed new medication should be monitored closely on how it may affect the patient’s outcome. It also states that drugs with higher efficacy can produce more significant effects than lower efficacy drugs (Woo & Robinson, 2016, p.14) Bioavailability refers to the extent of a substance or a drug that becomes available to its intended biological destination in pharmacology. Therefore, bioavailability measures the rate and fraction of the initial dose of a medication that successfully reaches either; the site of action or the bodily fluid territory from which the drug’s intended targets have unimpeded access. The text gave an example of and 500mg oral dose of ciprofloxacin that can be substituted for a 400mg IV dose of ciprofloxacin, which makes up about 80% of its oral availability (Woo & Robinson, 2016, p.19). 17. What are potential adverse effects associated with BBs according to the text? What lab abnormalities can occur? According to the text, there are several potential adverse effects for beta blockers (BB’s), and the text classifies them according to each body system, which I will outline for discussion purposes here as well. For the CV system, BB’s can cause hypotension, bradycardia, and CHF without pulmonary edema. In the respiratory system, BB’s may lead to bronchospasm and dyspnea, which is why they are used in precaution for patients with bronchospastic disorders such as asthma (Woo & Robinson, 2016). Fatigue, weakness and dizziness are all CNS effects that may occur secondary to hypotension, and anxiety, depression, drowsiness, nightmares and insomnia may occur in BB’s with high CNS penetration, or in older adults (Woo & Robinson, 2016). BB’s can also cause instability in blood glucose levels, especially for patients with diabetes due to alterations in carbohydrate metabolism. Changes in GI motility can lead to anorexia, N/V or constipation (Woo & Robinson, 2016). In the GU system, BB’s may cause impotence and decreased libido, which can be a reason for medication noncompliance. Less common reactions include myalgias, skin rashes, and facial edema (Woo & Robinson, 2016). Lab abnormalities associated with BB’s include elevated uric acid levels, BUN, serum lipoprotein, potassium and triglycerides (Woo & Robinson, 2016). Glucose levels NR 565 MIDTERM REVIEW LATEST UPDATED 2024 TOP RATED EXAM STUDY GUIDE FOR GUARANTEED SUCCESS. patients with severe coronary insufficiency, recent MI and renal function impairment. NR 565 MIDTERM REVIEW LATEST UPDATED 2024 TOP RATED EXAM STUDY GUIDE FOR GUARANTEED SUCCESS. Clonidine should be avoided in patients with a history of bradycardia. According to the U.S FDA (2019) common side effects include dizziness, dry mouth, upset stomach and feeling tired. According to Woo and Robinson (2016) side effects may also include urinary retention, bradycardia, hypotension and chest pain. These side effects are key patient educational points and to report these to the provider in addition to taking these drugs as directed.