Common Issues in Ethical Review of Research: A Perspective from Pakistan, Slides of Biotechnology

Download Common Issues in Ethical Review of Research: A Perspective from Pakistan and more Slides Biotechnology in PDF only on Docsity! Common issues in ethical review of research: a Pakistani perspective Docsity.com Outline • Research scenario in Pakistan • Issues  Training deficiencies  Misinformed consent Conflicting interests  Review process Docsity.com INTERNATIONAL IRBS FOR PAKISTAN (12) [NEW SEARCH Find Institutional Review Boards in table below and click corresponding Detail link to view details: ituti Navigate tei a Eaasnay Boards IRB Number Institutional Review Board City IRBOO001234 AGA Khan U IRB #1 Karachi Detail IRBOOOO1794 National Ctr Excellence in Molecular Biology U IRB #1 Lahore Detail IRBOOOOZ208 Health Oriented Prev Education (HOPE) IRB #1 Karachi Detail TRBOOOOZ510 Nai Zindagi IRB #1 Islamabad Detail IRBOOOO2993 ARI Rech CELL IRB #1 Islamabad Detail TRBOOOO3084 Sindh AIDS Control Program IRB #1 Karachi Detail IRBOOOO3157 Bridge IRB #1 Karachi Detail IRBOOGO3532 Quaid-I-azam U IRB #1 - Biomedical Islamabad Detail IRBOOGOS148 Interactive Research and Development. IRB #1 Karachi Detail IRBOOGOSZ81 School of Biological Sciences IRB #1 Lahore Detail IREQOOOS335 Human Development Research Foundation IRB #1 Islamabad Detail IRBOOOOSS56 Faculty of Biotechnology ¢Informatics IRB #1 Quetta Detail ww.hhs.gov/ohrp/humansubjects/assurance/renwirb.htm Docsity.com Issues Docsity.com Training deficiencies • Undergraduate and postgraduate • Lack of opportunities • Dearth of capacity • Over-training versus non exposure Docsity.com Misinformed consent • Confusion between research and clinical care • “Randomization”, “placebo” or “control”, “double blind” translated literally “Placebo” translated as “ineffective drug” Docsity.com Conflicting Interests • Incentives for researchers • Incentives for recruitment Docsity.com Conflicting interests: incentives for researchers • Level of compensation for Principal Investigator • Reward for recruitment of subjects for research officers What is the role of IRB’s in this? Docsity.com Recommendations • Enhance IRBs’ capacity to review beyond guidelines • Probe potential conflict of interest areas • Informed consent should be contextual – written for subjects who can read and write – verbal and witnessed for subjects who cannot read and write Docsity.com Recommendations contd. – audio-visual materials, brochures etc. to communicate complex information – translations should capture concept • Lack of adequate health care infrastructure requires IRBs in developing world to be more vigilant Docsity.com