Pharmaceutical Chemistry Synthesis of Aspirin Principle, Study Guides, Projects, Research of Pharmaceutical Chemistry

Download Pharmaceutical Chemistry Synthesis of Aspirin Principle and more Study Guides, Projects, Research Pharmaceutical Chemistry in PDF only on Docsity! Pharmaceutical Chemistry Synthesis of Aspirin Principle : Synthesis of Aspirin from salicylic acid occurs by acetylating process in acidic medium. Salicylic acid interacts with acetic anhydrides in presence of few drops of conc. sulphuric acid to produce aspirin and a molecule of acetic acid. The purpose of adding sulphuric acid (catalyst ) is to aid and augent the process of detaching the acetate ion from acetic anhydride which ultimately get associate with H+ ion from phenolic hydroxyl group in salicylic acid to be eliminated as a mole of acetic acid. Chemical Reaction : Mechanism : Uses : Use for the relief for minor pains/ aches and also mild to moderate pain. It is recommended for arthritis and related arthritic conditions, myocardial infarction prophylaxis. It reduces the risk of transient ischemic attacks in men. Synthesis of Paracetamol : Principle: The synthesis of amide essentially just requires running the reaction under certain temperature conditions with an appropriate catalyst . Pracetamol prepare from para-amino phenol by acetylating it with acetic anhydride in the presence of 3 to 4 drops of concentrated sulphuric acid as catalyst. Chemical Reaction Mechanism :