Rxn Summary Alcohols, Phenols, Thiols - Mathematical Modeling | CHEM 2300, Study notes of Organic Chemistry

Download Rxn Summary Alcohols, Phenols, Thiols - Mathematical Modeling | CHEM 2300 and more Study notes Organic Chemistry in PDF only on Docsity! Chapter 7 Rxn Summary (Alcohols, Phenols, Thiols) 1. Preparation of Alkoxides R-OH + Na R-O- Na+ + H2 + NaH (NaOH is not strong enough of a base to form alkoxides, but will form phenoxides from phenols) 2. Dehydration C C H OH H2SO4 (or H +)  C C + H2O Zaitsev’s Rule: The major alkene formed is the one with more alkyl substitutents on double bond. 3. Conversion to Alkyl Halides (X = Cl, Br) 3o, 2o R-OH HX R-X 1o R-OH HX R-X ZnX2 also: SOCl2 PCl3 PBr3 4. Oxidation 1. Jones Reagent: CrO3, H + 2o R-CH-R OH R-C-R O (ketone) 1o R-CH2-OH R-C-OH O (carboxylic acid) 2. PCC, Pyridinium Chlorochromate (aldehyde)R-C-H O 1o R-CH2-OH (ketone))R-C-R O (2o R-CH-R OH