Williamson ether synthesis of Acetaminophen to Phenacetin, Summaries of Organic Chemistry

Download Williamson ether synthesis of Acetaminophen to Phenacetin and more Summaries Organic Chemistry in PDF only on Docsity! The Synthesis of Phenacetin from Acetaminophen Introduction Acetaminophen, also known as paracetamol, and phenacetin (both shown in Figure 1) are non- opioid analgesics. Acetaminophen was first synthesized in 1877, and first used in humans in 1887. It is the most widely used, non-anti-inflammatory medication for mild to moderate pain relief and fever reduction. Phenacetin is an analog of acetaminophen and was utilized for nearly 100 years until the FDA banned its use in 1983 and all products it was contained in. Although it was effective as a non-opioid analgesic, physicians and the FDA had concerns with its carcinogenic properties as well as its negative effects on the kidneys. Figure 1. The structures of acetaminophen and phenacetin OH N H O acetaminophen OCH2CH3 N H O phenacetin The synthesis of phenacetin from acetaminophen will be accomplished via the Williamson-ether synthesis. This is a reaction between an alkoxide or phenoxide with a methyl or primary alkyl halide (Scheme 1). Scheme 1 depicts an ethoxide reacting with methyl iodide to yield the compound ethyl methyl ether. Scheme 1. The synthesis of an ether via the Williamson-ether reaction O CH3I, DMSO O ethoxide ethyl methyl ether Scheme 2 shows the reaction that will be performed in this experiment. Acetaminophen is treated Scheme 2. Phenacetin synthesized from acetaminophen using potassium carbonate OH N H O K2CO3 , CH 3CH2I O , reflux, 1 h acetaminophen OCH2CH3 N H O phenacetin with anhydrous potassium carbonate and ethyl iodide, while 2-butanone is employed as the solvent. The reaction is heated at reflux for 1 hour and then put through a series of workup steps. Pre-lab Questions: 1. What kind of solvent is used in this reaction? Polar protic, etc? 2. What is the role of potassium carbonate? 3. What is the name of the mechanism that this undergoes? E1, etc. 4. What is the theoretical yield of the product? Prelab Outline: Make sure to outline a good prelab so you could perform the experiment without this handout. Your table of reagents should, as always, have mass, mmol, volume used (if applicable), physical properties (mp, bp, densities if applicable, etc.), and any hazards, of course. The Procedure: 1. Set hot plate to 225 +/- 5 °C. 2. Add acetaminophen (500 mg), K2CO3 (665 mg), and 2-butanone (aka. methyl ethyl ketone, 7 mL) to a 25 mL RBF. Please note that the K2CO3 will not dissolve. Add ethyl iodide (0.64 mL) via syringe followed by the football-shaped magnetic stir bar. 3. Turn the stirrer on to low. The stir bar should be allowed to spin at a rate to sufficiently mix the heterogeneous solution. 4. Attach water jacketed condenser and reflux for 1 hour. Do not start timing until the solution has reached reflux. Clamp the neck of the RBF, not the condenser. a. Remember water goes in the bottom and out the top. b. Attach a clamp holder to the end of the drain tube to keep it weighted in the drain. c. Turn water to a trickle. If it is slowly draining, it is high enough. 5. After 1 hour has expired, raise your apparatus out of the aluminum block, remove block from the hot plate (USE HAND PROTECTION!), reduce heat to 50 °C and let the RBF cool to the touch. Reaction Work Up: 1. Add 4 mL water to the RBF and allow the solid to dissolve. 2. Turn off the stirring and transfer the contents to a 25x100 mm culture tube. This will be called the X-large culture tube, or XLCT, and can be found on the common equipment bench. 3. Rinse RBF with tert-butyl methyl ether (TBME, 4 x 1 mL) and add each rinse to the tube. 4. Remove bottom (aqueous) layer and place into centrifuge tube. 5. Backwash the centrifuge tube with TBME (1 x 2.5 mL). Mix layers well with pipet, allow layers to separate, remove lower layer and place into a waste beaker. Add the organic layer to the XLCT. 6. Extract contents of XLCT with 5% NaOH (2 x 4 mL). 7. Wash with brine (1 x 5 mL). 8. Dry organic layer with CaCl2. Let stand for 5 minutes.