Rank Analysis of Treatments for Reduced Mortality in Critical Care Patients, Guías, Proyectos, Investigaciones de Farmacología

¡Descarga Rank Analysis of Treatments for Reduced Mortality in Critical Care Patients y más Guías, Proyectos, Investigaciones en PDF de Farmacología solo en Docsity! Fuentes 1 https://www.sciencedirect.com/science/article/abs/pii/S0883944116303422 2017 2 https://www.sciencedirect.com/science/article/pii/S0304541215003017 2015 4 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0129305 2015 Rank analysis showed that among treatments found to be significantly associated with reduced mortality, levosimendan showed the highest probability to be the best (85%) followed by dobutamine (65%), the combination of norepinephrine plus dobutamine (64%), epinephrine (60%), and vasopressin (59%) (Supplementary Fig. 2 in Supplementary Material). Results of a traditional meta-analysis comparing levosimendan vs dobutamine showed no difference between the 2 agents in terms of mortality (risk ratio for levosimendan vs dobutamine, 0.78; 95% CI, 0.56-1.09; I 2 = 0%, with 4 studies included [28,42,44,45]) (Supplementary Fig. 3 in Supplementary Material). There was no significant heterogeneity/inconsistency among comparisons investigated (I 2 = 0%; Q statistics P value whole network, P = .99; within designs, P = .99; between designs, P = .94). Heat plot showed mild inconsistency only among terlipressin vs vasopressin vs norepinephrine comparison. Finally, inspection of comparisonadjusted funnel plot did not disclose significant small study effects or publication bias (Supplementary Fig. 4 in Supplementary Material) (1)